it seems like everybody tend to misunderstand...Physically there is nothing stopping him. He has both Juugo's cells that naturally gather NE as well as Hashirama's. Even if he didn't the notion of sasuke having a weak body is false
it`s not that he has a weak body....but his chakras are YIN oriented and therefore he is more gifted for spiritual jutsus and such...
as for SM and its proper use YANG is dominant as its traits are that of physical and people with more of a YANG type find SM a lot easier and better to use
sasuke can learn SM and control some of its energies which we saw but i dont think he can utilize SM to its real extent