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Not really. Cause otherwise Senju can't do sage mode.. but seeing as Naruto did. It is still possible.
Based on the facts that SAGE mode interacts with the contract with the creature they bound with, originally its a development, or precisely an evolution from that said creature i.e toad. Like Kabuto he just develop new evolution of his power-ups and encounter dragon mode which not in conflict with his nature chakra because he didnt have any restrictions from any bloodline. As far as we all know, there's only 2 disciples of toad sage which is J-man and naruto, and none others. Kabuto SM was not clearly stated as from who and what, but based on toad SM, kabuto must have been with the contracted Manda which grants him the SM.