Prime Hiruzen would stomp & crush anything Sasuke has to offer into pieces including his existence, hell add in Adult Sakura and it still wouldn't change the outcome. Naruto on the other hand low diffs Hiruzen via clone and RS.
Sasuke'd stomp Hiruzen and his comparitively low level techniques while on the other hand, anything Naruto has to offer'd be stomped & crushed with below low difficulty. Add Gai into the fray, and the result is still a stomped match from the part of Hiruzen.