No Orochimaru cannot kill a Uchiha with MS,a sharingan has nothing to do hurting orochimaru (Kakashi can't do half the stuff a Uchiha can all he has is Kamui); he would beat kakashi like he stole something. Your talking about Orochimaru the same orochimaru that" was able to hold his own against a four-tailed Naruto in Part II while his body was in a weakened state, and despite the danger Naruto imposed, he found the battle highly entertaining, even playing with Naruto's initial three forms. Even then, his body gave in, he expressed regret that he couldn't complete the battle. Even among the Sannin, he was the one who originally stood out for individual ability. "The same guy who can whoop ass without his arms, the same guy who" is an extraordinarily powerful ninja, being Kage-level in his own right. He was also considered as a child prodigy that appeared only once a generation."
Your are either a troll or just not reading the manga closely cause Kakashi ain't two sh*ts compared to Orochimaru.