Sakura solos
she will hit ground and game over.
Lols at that...
You really think she can take down both Neji and Chouji with 1 punch??
Sure, he punch deals damage to a great area, but most of the damage is dealt at the center.
Sure she'll still deal some damage to them if she simply punches the ground. But to take them out for good she has to land a direct hit.
OT:
I could honestly see it going both ways.
If Neji and Chouji think this trough they'll take out Lee to begin with. If they work together they can take him out pretty fast. And yes Sakura will be a nuisance while trying to take down Lee, but if they don't let their guard down they can do it without taking too much damage.
Then it'll be 2 vs 1 and don't see Sakura has no chance of taking that without Katsuyu. Neji alone would be problematic do to his speed, put in Chouji to throw some of his Gigantic Punches at her and I she simply can't keep up.
She'll eventually get hit by 64 palms (Or a Chouji Punch followed by 64 palms) and from all we know Byakugō wont help against that.
On the other hand Sakura and Lee could also team up to take down Chouji early on and then it'd be Lee and Sakura vs. Neji.
And Neji surely can't take down both of them, that'd be crazy.