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Jupiter

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Izanagi can only be used by those with the genetic traits of the Sage of the Six Paths. The Uchiha, descended from the Sage, are able to perform Izanagi with their Sharingan. In exchange for the brief control of reality that it allows them, the Sharingan with which Izanagi is cast becomes blind. For this reason the Uchiha labelled it a kinjutsu. Danzō Shimura, in an effort to make practical use of the jutsu, had ten Sharingan embedded into his right arm. He also had Orochimaru extend the lifespan of each Sharingan's Izanagi to a minute, allowing him to use the technique for up to ten minutes, with breaks in between as he deemed necessary. However, because Danzō is not an Uchiha, his chakra levels drop substantially every time a new Sharingan is used to activate the technique.

To make full use of Izanagi, users must also have the genetic traits of the Senju, who are also descended from the Sage. For this reason Danzō had some of Hashirama Senju's DNA transplanted into his arm, which had the added benefit of increasing his physical energy and vitality. Madara Uchiha also makes use of Hashirama's DNA, though he claims to have gained control of it, unlike Danzō.
 
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