Uh, this is difficult. Nagato, Madara and Itachi from "Naruto" have done very awesome speeches, but I'll go with other ones now:
"You must never give in to despair. Allow yourself to slip down that road and you surrender to your lowest instincts. In the darkest times, hope is something you give yourself. That is the meaning of inner strength."
- Uncle Iroh, The Last Airbender
"When you base your expectations only on what you see, you blind yourself to the possibilities of a new reality."
- Zaheer, Legend of Korra
"You think freedom is something you can take or give on a whim. But to your people freedom is just as essential as...Air. And without it, there is no life. There is only....Darkness."
- Zaheer, Legend of Korra
"So, we lucky few. This band of brothers and sisters in anarchy, are witnessing the beginning of an era of true freedom. Together, we will forge a world without kings or Queens, without borders or nations, where man's only allegiance is to himself and those he loves. We will return to the true balance of natural order."
- Zaheer, Legend of Korra
"Let go your earthly tether. Enter the void. Empty and become wind."
- Zaheer, Legend of Korra
"Neither of us are the same as before. I learned to fly, but now I'm bound in chains. You have all the power in the world and the freedom to use it, but you choose to hold yourself down. [...] You're wrong. That poison should've killed you, but you were able to fight it off. You think your power has limits; I say, it's limitless."
- Zaheer, Legend of Korra
"Growing up in Zaofu, with Suyin Beifong, I learned that the idea of a royal family passing a title from one generation to the next was archaic, and that technology and innovation should be what drives a nation forward. It was the pathetic rule of kings and queens that caused the Earth Kingdom to descend into such incredible disarray. It's taken me three years to get it back on track, and there is no way I will allow it to slip back into the dark ages. I'd like to make an announcement to the world: the Earth Kingdom is no more. And from here on out, this man has no authority. [...] I have created a new Earth Empire, and I will continue to lead it into the future myself, bringing about a new era of prosperity for my people. And let me assure my fellow leaders of one thing: Anyone who crosses our borders or stands in our way, will be crushed."
- Kuvira, Legend of Korra
"I see now that the circumstances of one's birth are irrelevant. It is what you do with the gift of life that determines who you are."
- Mewtwo, Pokemon Movie 01