Lightning jutsu is naturally strong against an earth jutsu, and weak against wind. Lightning also has a unique relation with water since water conducts electricity. This means that a Water Release technique can be used to increase the damage of a Lightning Release technique.Though this also means that if one's opponent still has a physical connection with the water, either a pre-existing source or one created with their own chakra, then they can be paralyzed via their own jutsu. Based on the exhaustion of using Lightning Release techniques, it can be presumed that they require more chakra than the other nature transformations.
In addition, along with water, lightning is one of the components for the Storm Release nature.