I did not forget that he lost all of his siblings. That's why I mentioned that they played by the same rules. There were loses on both sides of the fight.
There were losses on both sides of the fight, however Izunas last words to his brother when he had recieved the fatal injury from Tobirama were "Not to trust the Senju."
Those last words were said at the time Madara was contemplating listening to Hashirama, however we later see when Madara returns with the Eternal Magekyo Sharingan that Izuna had entrusted his eyes with the legacy of protecting the Uchiha clan (although something about this doesnt sound right - i'm sure we were previously told that Madara obtained Izunas Sharingan after his OWN eyes had started to fail him??? hmmmmm..... Madaras eyes seemed pretty fine in that battle in my opinion)
Back to the point, if that was then the case, the last thing Madara was told by Izuna was to not trust the Senju, and to preserve the Uchiha. Madara to me seems broken at this point. and the difference between him and Hashi is that he is an Uchiha: and out of Love the cycle of hatred started: reflecting in his eyes.
EDIT: And lets not get it twisted. I rate Hashirama 100%, however i can see both sides on this story. All madara needed to do was trust Hashi, but his pain was too great, leading to resentment amd hatred.
In telling Hashi to either kill jimself or his brother, he was saying that his pain was to great. at that point he is too fargone to hear reason anymore. and you can see the man is in pain.