I think Orochimaru takes this. His biggest weakness is apparently a Sharingan. As for Itachi and Kisame tying, I find it hard to believe a healthy Itachi, like the one who got Orochimaru so easily, would ever tie if he actually intended to kill Kisame. So that comparison is moot.
it'd be a tough fight for sure, but I can't see Kisame winning.
it'd be a tough fight for sure, but I can't see Kisame winning.
Versus threads are allowed only in the Versus section and I'll go with Oro.