Kakashi wins this IMO.
Kakashi has to much for her to deal with.
Kakashi is better at ninjutsu that's obviously.
Kakashi is better at taijutsu as well IMO, his Sharingan boosts his taijutsu capabilities and Being Guys partner and rival also helps that.
Even with Tsunades Mitotic Regeneration she cannot regenerate a missing head from kakashis Beheaders blade with Raiton running through it.
Tsunade maybe only wins this if she summons Katsuyu and has her melt him.
I don't know if Kakashi has any jutsu to deal with giant summons.