If it's Double Edo than Itachi would win only because he's the only one known to have any kind of sealing power/jutsu. However if it's not Edo and their both alive, Madara would most likely within a few seconds. Seeing as Madara has Susanoo just like Itachi, I'm sure he's also aware of a weakness too it (Possibly).
tell me r u talkin about in edo forms or withour edo forms
lets just wait and see. look at madara being cocky that he thinks he's the strongest and thinks no one had surpassed hashirama. if it wasnt for that dna and kabuto's experiment he is a DOUBLE DEAD ninja as of now :rofl:
How ridiculous is this discussion? Even with EMS only Madara would be stronger than Itachi. He possesses a stronger Sharingan, the Rinnegan and Mokuton. Itachi don't have any chance.