big tits, rinnegan, super strong = epic ninja
She's also Uzumaki, too.
No, she's a senju.
50 isn't a set age for Menopause. Why is this site populated by a bunch of ignorant kids? I know plenty of women over the age of 55 who have had kids and are perfectly healthy.
As for the question, Sasuke isn't 16, he should be 18 now considering the time line. He's legal, but I doubt he's interested in Tsunade and viceversa.
She's probably already had her menopause dude