50 isn't a set age for Menopause. Why is this site populated by a bunch of ignorant kids? I know plenty of women over the age of 55 who have had kids and are perfectly healthy.
As for the question, Sasuke isn't 16, he should be 18 now considering the time line. He's legal, but I doubt he's interested in Tsunade and viceversa.
1. This site is a fanbase for Naruto, a
cartoon/anime. Did you expect it to be populated by educated adults? Ironically, you're the one seeming ignorant here for forgetting that. Also the fact that *you* know old women irl who have had children is irrelevant...this is an anime. It's fantasy, not reality. If people want to imagine that Tsunade has reached the phase of menopause in her life due to her age, they have every right to, without being called "ignorant kids".
2. Sasuke was born shortly before Naruto and he told his father during the Pain arc that he was 16 years old. This makes Sasuke 16, or in the more unlikely circumstance, 17 years old.
I have nothing against you but try not to act like a know-it-all internet badass on a forum populated mostly by younger people.