In terms of abilities.
Both have a power up mode:
Sage mode vs Byakugo mode.
Essentially both can't really be killed easily. Hashirama would have better sensory abilities and equal healing abilities. While Tsunade would have greater strength.
Only thing is Hashriama is way more skilled, he could go head to head with Madara in kenjutsu and CQC alone. While Tsunade struggles with kabuto part 1.
So Hashirama is still above her without his wood I beleive.
