Deidara -> She has Byakugou, so she's basically immortal for some ammount of time. The biggest problem I see would be his last techique, but if Tsunade activates the jutsu, she's ok.
Sasori -> Sakura beat him. She was trained by Tsunade so, you know the resu
Kisame -> He could be troublesome to ber, indeed, so maybe with high diff. she would win.
Itachi -> She could take this. All itachi has against her would be the Tsukyomi but we've seen Tsunade healing Sasuke, so why shouldn't she be able to heal herself? Although he is pretty intelligent. Maybe a draw?
Kakuzu -> I'll give it to her cause she has many evasive skills and 5 hits would be enough to get him done. Kakuzu withouth those hearts would kinda be nothing.
Hidan -> If she figures out his jutsu, he's done, if not she's done.
Nagato -> As much as I like Tsunade, don't think she could win over him but Nagato would take this with mid-high difficulty. Why I say it? Because she has many things in her sleeves and she wouldn't have to take care of the rest of the village, just herself.
Tobi -> Haven't seen much of him but I think he takes this. If he's not to be caught, she can't do anything to him. The only one who won was the 4th, who had the well-known speed.
konan -> Tsunade takes this. Many of Konan's techniques are paper based. One word: Katsuyu. Acid melts paper.
So yeah, this is kinda it if you think logically.
