Sasuke binds them with white snakes , then stabs them both.
By portrayal tho i think kishi would have tsunade and co edge out a extr high diff win against him , assuming sasuke would have manga intel tho.
Tsunade is hyped as a elite evader and preaches evasion , deidara was able to react to a shunshin blitz from sasuke twice and i see reason why deidara would have better reaction than tsunade and war arc sakura especially since tsunade is hyped as having superior taijutsu skill to oro and oro>>hebi sasuke in tajutsu. Tsunades feats against madara were also noteworthy testament to her skill in the field , with sakura by her side she can effectively counter any run nd dash swing tactics from sasuke and catch him off-guard by quicky attacking the ground at his feet by casually steping on it while his sharingan is focused on their upper body then demolish him.