Alright, so let me get this straight, so you think that Tsunade can handle: ( copy links and put them on a new tab )
This:
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This:
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This:
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This:
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This:
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This:
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This:
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This:
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This:
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All that being done in Sage Mode, but wait, there's more.
You also think that she can handle:
This:
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This:
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This:
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This:
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This:
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And you also think she has the ability to handle these:
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Who're capable of doing:
This: ( Clones that are able to make clones and use Giant Rasengans )
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This:
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And are capable of redirecting the RasenShuriken, making dodging almost completely useless ( replace the Raikage with Tsunade ):
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And she said herself, she can't heal the damages done by Rasenshuriken as you can see here:
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So sorry bud, but if Tsunade gets hit by this, her ninja days are over, she can't heal anymore, and she can't use anymore techniques, she'll be on the ground unable to move and even if she could, she'll feel as helpless as Naruto after Neji uses the 8 Trigrams 64 Palms ( before Naruto resorted to using Kurama's chakra )
But in the situation that plot shield ( the only way she would
ever win a fight like this ) helps her to push Naruto in a corner ( in which I doubt could happen ), then Naruto will use Bijuu Mode, and after that I would really be heart pressed to see Tsunade trying to fight against a mode that is capable of doing:
This:
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This:
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This:
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This:
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This: ( I know this is KM, but I'll put it in just for kicks )
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( you can replace Tobi with Tsunade and imagine some KM or some BM clones fighting her, and you could imagine her being overwhelmed by those clone's abilities to use chakra arms and use techniques with those arms, and she is surrounded, as soon as she turns around like Obito does any of those Naruto clones could throw a Mini Bijuu Bomb Rasengan and vaporize her )
Just like I showed you with Rasenshuriken he can redirect it or use a clone feint to overwhelm Tsunade with Naruto's Kage level clones and use this to hit her in her blind spot as you can see here:
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effectively keeping her on her toes and keeping her on the move, but again, Tsunade is slower than the Raikage ( as stated by Madara ), since KM is faster than A and BM is even faster than that with a more durable cloak, Naruto's clone feint will end in Tsunade's inevitable vaporization ( and we all know, you just can't regenerate from nothing )
Here is the power of the Mini Bijuu Bomb Rasengan Technique:
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Of course, Madara being the boss that he is, uses Naruto's technique against him, but again, since this is Naruto vs Tsunade, if Tsunade gets hit by this technique it would again vaporize her, you can't doubt the power that this technique has since it took out a BM clone, those are very durable, more durable than KM clones.
Naruto's Bijuu Mode can also use Kurama's tails to manipulate objects like shown here ( helping to overwhelm her even more ):
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And if Katsuya does manage to trap Naruto's Kurama cloak ( which is highly unlikely ) then Naruto could simply dispel the cloak and shunshin out of there.
And to make it all worse, Naruto can make clones in Bijuu Mode, and clones can do everything the original can as shown here:
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Feel free to replace the Gedo Mazo with Tsunade and her Boss Summon Katsuya. Twist it however you want, I do not see how Katsuya and Tsunade can tank this if this is equal to five bijuu damas that can take out entire mountain ranges.
What makes it worse? He can spam it:
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And the Kurama cloak is very durable, it can withstand an incomplete Juubi laser as shown here:
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And Kurama's combat experience can help Naruto come up with a stategy to defeat Tsunade.
Since Naruto merged with Kurama his healing capabilities also increase.
Anyway with that said, Tsunade is going to have major problems fighting Naruto's clones, backing her in a corner and overwheling her, and since Naruto is unpredictable he can simply disguise some clones as surroundings, setting Tsunade up for getting hit by multiple Oodama Rasengans, and Kurama will warn Naruto to make sure she can't regenerate, so then he'll finish her off with a Flash Bijuu Dama and it's game over( or he could use clone feints and have Naruto's kage level clones overwhelm Tsunade and then hit her with a Rasenshuriken and then she can't use any techniques anymore, because she said herself, she can't heal it ), Naruto takes this Mid-High difficulty and that's just being generous. ;D