Opinion.Tsunade gave Naruto the necklace and the 'kiss' so she wanted him to be Hokage.
She will give up the Hokage seat for Naruto, so her death is not a factor.
She won't just give it to him because she isn't that type of kage....she's tough.
If anything Naruto wouldn't even accept it because he knows a lot of people want to be hokage including sasuke.
There would be a brawl, but also my opinion.
I have 99% sure that anything we think of is going to happen because its Kishi. Obvious thinking isn't his thing.