If Sasuke knows how his technique works, with Sharingan perception he can probably win. But using big Susano'o is a suicide, he'd need to go ribcage combat.
Chidori Nagashi is Sasuke only hope, and only if he has knowledge on Kamui. That would stun Obito the moment he because solid and tried to warp him. Unfortunately for Sasuke, he doesn't know how Kamui works, so it's gg.