Yeah I think so, i honestly think that by the end of the series all 3 sannin will be dead.
Did you see it, didn't you? Tsunade is into pieces... but i'm not sure if she trick him that she's already dead or Madara let her to die in agony...
Well Tsunade can still move and summon, so it must not be that bad haha.
It's plot no jutsu.