I am normally a huge sucker for romance, but the fact that romance, sexual tension and desires are either totally unimportant, absent or portrayed in such an awful manner in this series sort of make pairing and shipping seem stupid. I appreciate some fans' attempts at trying to flesh out the interesting sandbox Kishimoto has created, but the problem is that I generally don't care about the vast majority of the characters in Naruto. Support characters have limited screen time and personalities for the most part, so why do I care who they hook up with?
If I were to say which pairing has the most promise, I'd say it's Shikamaru and Temari. They're fairly average people, coming from two different villages, and then it's the fact that their personalities sort of blend together nicely. Of course, they haven't been seen together since early Shippuden so...