Well : Naruto and Jiraiya's relationship was a Grandson/Grandpa's.
Tsunade and Sakura's is shown to be strictly teacher.
Orochimaru and Sasuke have more connection. Also, no notice how Orochimaru is actually caring how Sasuke is feeling. He is looking after Sasuke.. he is following Sasuke. Sasuke doesn't talk to Orochimaru with respect..just like how Orochimaru used to treat him like a experiment. BUT OROCHIMARU IS CHANGING... And I really I hope he does. Because personally the evil orochimaru was pretty creepy and boring.
Plus, he seems pretty proud that Sasuke is advancing.
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Not really. He literally referred to Sasuke as his "experiment". No connection whatsoever. And, creepy, evil Orochimaru was absolutely amazing and easily one of the best characters in the entire show.