Yes Tobirama, Hiruzen and Minato can beat Hashirama; all 3 of them have better battle smart feats than him and all have skills that can help them win the fight. Tobirama is the same level as Hashirama and Madara, he's just weaker than both ( MS Madara was capable of fighting on Hashirama level, lost but still fought on that level. Tobirama killed Izuna who was said to be Madara's equal). He knows his brother's fighting style and was stated by Madara to be the fastest of their time so Hashirama isn't touching him. He was the one calling the shots after joining the war and his strategies allowed him to hit Juubito who was physically faster than them. He also has a pretty high chakra reserve and have jutsus capable of cutting a branch off of the God tree so doing it on Hashirama's wood jutsus should be a problem. He has FTG which can teleport anything he or his chakra touches, he can flood the area with water (as his Edo form did in part 1 against Hiruzen) then FTG anywhere his water touches or FTG anyone who is on his water since its created by his chakra. He's also a sensory type which only makes his reflexes even better than they already are.
Prime Hiruzen was stated to be the strongest Hokage while old Hiruzen stated to be the strongest Kage in part 1. Hiruzen was trained by both Hashirama and Tobirama so knows of both of their fighting styles which can help him fight Hashirama and fight as a team with Tobirama. Hiruzen has a large chakra reserve, he even had Kage level chakra in his old age and it was said to be lower than when he was younger. He can use all 5 basic chakra natures and know all non-KKG jutsus in Konoha. He's also really smart when it comes to ninjutsus, he can tell the jutsu from seeing the hand signs and can analyze it to try and find its weakness. His senses are sharp, able to locate and properly defend against attacks using only his sense of smell after Hashirama's genjutsus took away his sight and hearing.
Minato is really smart, he's able to quickly take the information that he has and piece it together to find a likely answer. He can breakdown jutsus by seeing it once and further break it down by seeing it more than once as he did with Chidori and Kamui; he even made the Rasengan after studying the TBB process. Minato is stated to be a genius that comes once in a generation and Jiraiya said they haven't had a genius like Minato since Minato and ninjas such as Neji, Shikamaru, Itachi, Sasuke, and Kakashi all came after Minato. He has a large chakra reserve, learning SM requires it; he has SM as well which is on the level Pein arc Naruto's SM is one (Naruto was told it doesn't last long and requires time to go into SM which are things Minato complained about SM plus he was low on chakra at that point so his SM wouldn't have been strong and I don't think an Edo could fuse with the Toad sages. Minato is pretty strong physically, he almost cut all the way thru Bee's tentacle with little to no leverage. SM increases Minato's base speed, strength, durability, recovery rate, chakra reserve, and jutsus power; so Minato's base speed and shunshin would made him much much faster (Edo's are weaker than alive forms plus Minato was low on chakra and SM awakens the body which most likely doesn't do on Edo since they're dead bodies). He's a sensor in base and it's even stronger in SM. Base Minato is skilled enough to fight A and Bee on more than one occasion and walk away from the fight and even leave such an impression that Bee trembles at the mention of his name.
Prime Hiruzen should have this alone but adding the other 2 makes it much more one sided. Now if you said Prime Hashirama which is Hashirama when he has Bijuus 2-9 under his control and actually uses them in battle then that's a whole different story but since he had Bijuus 2-8 when he fought Madara and Kurama, I don't see him using them either way.
