Akamaru and Sakura vs Asuma and Elder Monkey Enma

[SIR HERDERP PRESIDERP SDO]

Doubt it, since Enma's literally as hard as diamonds when transformed. However, her full powered punch would do a lotmore than a full powered punch from Sakura

I don't think Tsunade can break Enma but I agree that Tsunade can cause harm to him more than Sakura.