Mangekyō Sharingan
First main technique that Sasuke learned to use when he got Mangekyō Sharingan was Amaterasu. When Sasuke first used it unintentionally on Tobi, his right eye took Itachi's Mangekyō Sharingan form. When he later used it on his own, they took his own Mangekyō Sharingan form. Various characters have implied that his skill with Amaterasu surpasses Itachi's, as he is able to both control and extinguish the flames with his right eye. Sasuke is one of the rare few Uchiha who obtained the ability to use Susanoo, which he can use in the same manner as his Cursed Seal, manifesting single parts at a time; the technique's development is dependent on Sasuke's extreme emotion, usually anger. Sasuke initially uses incomplete versions of Susanoo due to various reasons. During his fight with Danzō, he uses a more complete version, and demonstrates its ability to use different weapons. Later on, during his fight with Kakashi, he perfected his Susanoo into an armoured form similar to Itachi's. Unlike Itachi, Sasuke's Amaterasu comes from his left eye, and Tsukuyomi along with his ability to manipulate and extinguish the black flames from his right eye. The last ability Sasuke demonstrated with his Mangekyō Sharingan was a technique that manipulates the black flames of Amaterasu known as Blaze Release.
How Sasuke can use this ability against 2nd Mizukage: Mangekyō Sharingan gave Sasuke great and unmachable techniques to many shinobis. Amaterasu, the strongest fire techique can burn almost everything and 2nd Mizukage's water can't stop it. It all depends if Mizukage could find a water source. But, even if he founds one, or makes one, he can't posibli do it as fast as Sasuke can throw Amaterasu flames. Sasuke has the greatest control over the internal flames, as he can evolve it into Blaze Release which is even faster and deadlier. Sasuke's ultimate defence - Susano'o is also a big advantage while fighting everyone. Man can't simply defeat it and 2nd Mizukage, while having no seriuous ninjutsu, can't brake through it. By counting on his exploding clone, 2nd Mizukage can't be sure if it will restrain Susano'o enough. It probably wouldn't.
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After learning that Sasuke can also manipulate Lightning Release nature manipulation, hoping to deter Sasuke from using the Cursed Seal, Kakashi taught him the Chidori, made more effective when combined with his Sharingan. With this combination, Sasuke can punch through most obstacles with relative ease, as well as severely damaging any opponent during most uses. In Part I, Sasuke was limited to using the attack only twice a day, with a third usage after the initial activation of his cursed seal. In Part II, Sasuke was shown to be able to use the Chidori several times in one day. During their battle, A commended Sasuke's Chidori for being able to break through his Lightning Release Armour despite inflicting only minor damage.
How Sasuke can use this ability against 2nd Mizukage: As stated before, Chidori-based Sasuke's techiques can't really har 2nd Mizukage. But, if he gets the chance to use Kirin, his strongest Lightning Release techiques, thing are very different. Kirin's distruction power and speed are too much for Mizukage to handle as it can reach the ground in 1/1000th of a second. Before using Kirin, you need to warm up the sky. Sasuke, as he knows how to use Amaterasu, can easily do it.
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As a true genius ninja and member of the Uchiha, Sasuke has great proficiency in Fire Release nature manipulation. By age 7, he had already mastered his clan's rite of passage technique, the Fire Release: Great Fireball Technique. Even Kakashi was amazed at such a feat as, according to him, Genin usually require much more experience and developed chakra to perform elemental techniques. He can also use his fire techniques in conjunction with his weapon skills.
How Sasuke can use this ability against 2nd Mizukage: Sasuke can't seriously harm Mizukage with his fire techiques. But, they are perfect to distract an enemy. They use a small ammount of chakra and Mizukage has to transform himself into water (Hydrification Technique) to avoid it. Perfect chance for Sasuke, who is relatively fast. He can attack the Mizukage and it's a check mate.
