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yes hiruzen did take out the first and third but that was before they were introduced as strong chacerters i say kakashi only because kamuis a one shot
It is avoidable though. But it's all up to Kakashi's aim & timing. Hiruzen is quick, even in old age, and combining high level A-Rank Jutsu just makes him a force to be reckoned with. That combination Fire Release: Fire dragon bombs & Earth Release: Earth dragon bomb would also one shot Kakashi. Unlike Orochimaru, Kakashi's body doesn't have heavy modification.