Could go either way. It would depend on whether Sasuke uses Amaterasu straight off the bat or if Kakuzu is allowed time for his hearts to separate. With his unique body, most of Sasuke's techniques will prove pointless in physically injuring him and being able to keep up massive elemental attacks will wear Sasuke out as long as Kakuzu is smart enough to have them attack from different directions. And since the hearts don't appear to have eyes or a brain, genjutsu would end up being worthless.
On the otherhand though, if Sasuke really focuses and attempts to cut down as many hearts as he can with his Chidori blade while he can maintain Susanoo, he could even the odds enough to give himself a better chance with ending things with Amaterasu before he gets worn out too much.
On the otherhand though, if Sasuke really focuses and attempts to cut down as many hearts as he can with his Chidori blade while he can maintain Susanoo, he could even the odds enough to give himself a better chance with ending things with Amaterasu before he gets worn out too much.