I don't know if this question has already asked or if it's stated in the manga, but is Itachi's MS still hurt him? Does it hurt when he uses Amaterasu, Tsukuyomi, or Susanoo? And even in Edo Tensai, will it make him go blind if he uses it too much? If it doesn't, this makes it similar to EMS, only without the enhanced abilities. This would make him a lot more powerful and dangerous.