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WTF read it again users must also have the genetic traits of the Senju....IT IS MUST HAVE
dude pls be reasonable read the link properly this is what it says i will copy and paste it
To make full use of Izanagi, users must also have the genetic traits of the Senju, who are also descended from the Sage. For this reason Danzō had some of Hashirama Senju's DNA transplanted into his arm, which had the added benefit of increasing his physical energy and vitality. Madara Uchiha also makes use of Hashirama's DNA, though he claims to have gained control of it, unlike Danzō
To make full use of it that means that it is better if one has both senju and uchiha dna that is all it does not mean that uchiha cannot use it at all.