this is automatically hashirama's win. as not to be biast to the conclusion, ill categorize everyone to their strongest suit and the ability of their best performance. ill focus on edo tensei itachi who has no illness and has no effects upon using his abilities vs hashirama sage mode (alive) itachi's badass techniques are the tsukiyomi, the amaterasu, susanoo (yatta mirror able to block any physical attack, totsuka blade "tortuga blade" able to seal any opponent it pierces) izanami, uchiha fireball techniques, ordinary sharingan genjustu and some water style techniques. hashirama's techniques comprise of water and earth elements thus forms the wood style justu he specializes in. he also can manipulate his wood style to form a golemn beast capable of going toe to toe with madara's complete body susanoo. hashirama has the abilty to heal from any injuries just as tsunade but unlike his grand daughter he does not need to form any hand signs "seals" to activate the healing process. his stamina and chakra strength are frighteningly incredible as he was able to take down both madara and kyuubi in the final valley beating them both. now the question itachi vs hashirama, my vote is hashirama because none of itachi's lethal techniques and big moves such as tsukiyomi and amaterasu or even izanami can halt hashirama. if he is hit by amaterasu, he will ofcourse burn but i believe he can heal through it. tsukiyomi is not a physical attack hence it poisons the mind weakening the body. kakashi was laid to waste to about i think three weeks and this was after he was healed by tsunade. hashirama can also heal through the tension that his body would endure due to the tsukiyomi. izanami affects those who try to change their destinies by either using the izanagi or just merely acting upon their character using foreign beliefs not common to themselves hence thats why it got to kabuto sage mode that easily for he was not content with himself. hashirama has never shown doubt about himself nor has he ever done things as sinister as kabuto. he cannot use the izanagi as well hence izanami becomes useless against him. itachi's big card would be now to use his susanoo which i can guarantee hashirama will still pound it to the ground. sure it can block any attack and seal anything it pierces but still the golemn hashirama used which is a match to a full body susanoo can beat itachi's susanoo. no matter how much it gets penetrated and sealed, it will just re-grow its limbs or any structural damage itachi's susanoo can do. hashirama can also use the deity gates and seal itachi's movements just as the way he did against edo tensei madara. hashirama's golemn has a wood dragon that can absorb chakra upon the targets it comes into contact with hence with accurate capture he can disfigure itachi's susanoo and win the beast fight. hashirama wins