Honestly, Itachi and Orochimaru are prettier than most of the girls in this series.
I can't blame Izumi for wanting Itachi in her bed at all (she wanted him as a husband, at least), and I'm surprised that no male or female character has commented on Orochimaru's looks past confusion. One would think that even someone as creepy as Orochimaru would have at least one admirer with how youthful and beautiful he looks.
I don't understand much of the hype surrounding the female characters in the cast. They weren't that pretty (unless some of you men are looking at something other than their faces? hmmm), Mei's hair was reminiscent of a Christmas tree, Konan has that ugly piercing, etc.