Sasuke fighting with PS in the Gaiden was the best thing about the whole crappy side shit.
He has the character, the abilities, and the style.
The only problem is the dailogue. Sasuke isn't very talkative, he would need someone to back him up whose also an interesting character for the most part.
You can't just write your story on one single person, you have to branch out and have different characters which makes the story interesting. Going by my opinion, he would definitely need some good allies to make the story more dynamic.