Not by much. Orosuke would have done some evil things as expected, with the new found power and his own power, he would be much stronger, but would have probably done the same things as Sasuke. But at some point, he would get overpowered by Sasuke and Sasuke would be released. The plot would still progress in the same direction, the results and events would be the same, all would happen in a different way. It would just be like taking a different path to reach the same point.
And all that is only going to happen IF Oro absorbs Sasuke. And Oro CAN'T absorb Sasuke because no matter what happens, he will always get owned by Sharingan in the transformation ritual.