He had a wife. That's because Obito calls Madara his ancestor. This means Madara had children.
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The VIZ page would give a clearer answer though.
That's a very risky assumption though.
Eh, that's not the Viz scan, it's Mangapanda, so what the characters are saying could be wrong cause it's not an official translation.
Still, See Obito's shocked reaction : He wouldn't have had such a reaction if Madara was not related to him by blood.
Then Obito goes on to say "My Ancestor Madara Uchiha !?"
Bold is proof enough that Obito and Madara are related by blood - A reason why Madara choose Obito as his successor ?
All of Madara's brothers died and they were never shown to have children. Even if they had children, they would have all died because of the war ravaged era taking many children's lives (Even Hashirama supported this idea).
Madara was the only one who survived the War Era and settled down in Konoha in a small period of Peace. He perhaps married a woman then and had a son or Daughter but later on abondended them in pursuit of the Moon Eye Plan.
Indra has a type, and Sakura was born yet.
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I think he had a wife and she may have died during the first or second ninja war.
Your uncle is your ancestor too, even if you're not directly related to him. In fact it may be possible that your uncle doesn't have any offspring. But They'll be called as your ancestor too.