I just realized that Tsunade and Sakura's strength should be useless against Madara and Sasuke or even Nagato. Chakra enhanced strength isn't actual super strength, it's just gathering chakra into one point, then releasing it all at once on impact. Take Sasuke for example, with his eyes, he should see the build-up of chakra into the fist and with his precog block the punch with his hand while using preta path. Logically the chakra released would get absorbed negating their strength completely. If you take away Sakura and Tsunade's strength you drastically limit their offensive arsenal.
Now this should be even easier for Nagato as we saw in his fight with Itachi, Naruto, and Bee he can absorb chakra from anywhere on his body, he absorbed Naruto's rasengan from his shoulder area Sakura and Tsunade's strength should be completely useless against him.
Now this should be even easier for Nagato as we saw in his fight with Itachi, Naruto, and Bee he can absorb chakra from anywhere on his body, he absorbed Naruto's rasengan from his shoulder area Sakura and Tsunade's strength should be completely useless against him.