JStar King
Sannin of the Scrolls 📜
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I found this and it explains it perfectly. This theory is very interesting.
What is Itachi Uchiha's mysterious "illness"?
As per what Tobirama said, the Uchiha develop their MS from knowing despair and great pain, and that their despair is reflected in how strong their eyes are. But he didnt mention the EMS, maybe because he didnt know about it or didnt have time idk, but it would follow the same principle. You must obtain a MS from a blood relative in order to unlock EMS, so that in turn would again fuel your despair and making the eyes stronger from knowing that pain of killing your family. And I think somewhere lies in the cause of itachis illness.*
Itachi knew despair, he had to kill off his clan and take up the mantle of a traitor, the scum of the earth, and in that his powers in his eyes grew to extreme levels. Itachi was nigh invincible with his Tatsuka Sword that can pierce and seal anything, and his Mirror shield that can block anything, along with susanoos defensive capabilities all these things reflect how much Itachi suffered in his life. And with those powers lied his problem, he was too powerful and without EMS he could support his use of those powers, so for the Uchiha, once they suffer they must keep suffering in order to survive.*
Basically his illness is a rebound of his powers on his body; his body isnt able to handle the power without a new power to help control his eyes. Like I said once the Uchiha suffer they must keep suffering till they die, because their bodies cant handle the strain of their eyes.
Just as Madara and his brother suffered to gain their MS Madara tried to remedy his rebound with his brothers eyes. And finally Madara took hashis senju cells to yet again stabilize the power of his eyes, resulting in the acquisition of the rinnegan. Which is something that Itachi couldnt achieve one because the only living Uchiha were sasuke and tobi, and Itachi wouldnt take sasukes eyes.
Essentially Itachis illness was a rebound of his vast uncontrollable MS powers.
The most visible symptom of Itachi's illness is hemoptysis.*
The hemoptysis is, more likely than not, a result of diffuse alveolar hemorrhage. This is a classic symptom of MPA when it presents with pulmonary manifestations. There is also shortness of breath, and coughing.
Unlike many other forms of vasculitis, such as wegener granulomatosis for example, the upper respiratory tract is usually spared. All the damage is deeper in the lungs. Itachi's case is consistent with this.
Other symptoms along the same vein can be seen during his final battle with Sasuke when Itachi grabs his shirt, reacting to what appears to be a heart attack.
Chest pain, myocardial infarction and other signs of cardiac failure are not uncommon effects of this disease, especially considering how it presented.*
It is also no secret that by the time of his death, Itachi was nearly blind. This, we know, to be a direct result of the mangyeko sharingan. When the mangyeko is used, it clearly puts a tremendous amount of strain on the eye, and the nerves and blood vessels that surround it. Needless to say, it's inflammatory in and of itself. But it is hasty to assume that Itachi's eye problems are caused by the mangyeko alone.*
Ocular involvement in MPA is uncommon, but can exist - usually in the form of retinal hemorrhage and scleritis. The bloodshot eyes Itachi sports in his final battle with Sasuke show these symptoms clearly.*
His low stamina as reported by the databook suggest constitutional symptoms of malaise and fatigue. The peculiar way he rests one hand in his cloak could be an attempt to alleviate painful sensations attributed to peripheral nervous system involvement manifesting as mononeuritis multiplex or myalgia, or simply to support a weakened limb. One could probably even argue his thin stature is evidence of weight loss.
Lastly, we consider the prognosis.*
The average age of onset is usually in the fifth decade of life, but cases around Itachi's age have been reported in medical literature.
The cause of the disease is currently unknown.
It is seen as an auto-immune disorder,
But because it doesn't have a tendency to run in families, it's not viewed as genetic. (Sasuke, after all, is still healthy.) However, it is theorized that there needs to be a trigger event, such as a disease or a major bout of inflammation that sets the production of antibodies into overdrive. This trigger could easily be the initial, or repeated, activation of the mangyeko sharingan, which as stated before, is clearly inflammatory in and of itself.
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I found this and it explains it perfectly. This theory is very interesting.
What is Itachi Uchiha's mysterious "illness"?
As per what Tobirama said, the Uchiha develop their MS from knowing despair and great pain, and that their despair is reflected in how strong their eyes are. But he didnt mention the EMS, maybe because he didnt know about it or didnt have time idk, but it would follow the same principle. You must obtain a MS from a blood relative in order to unlock EMS, so that in turn would again fuel your despair and making the eyes stronger from knowing that pain of killing your family. And I think somewhere lies in the cause of itachis illness.*
Itachi knew despair, he had to kill off his clan and take up the mantle of a traitor, the scum of the earth, and in that his powers in his eyes grew to extreme levels. Itachi was nigh invincible with his Tatsuka Sword that can pierce and seal anything, and his Mirror shield that can block anything, along with susanoos defensive capabilities all these things reflect how much Itachi suffered in his life. And with those powers lied his problem, he was too powerful and without EMS he could support his use of those powers, so for the Uchiha, once they suffer they must keep suffering in order to survive.*
Basically his illness is a rebound of his powers on his body; his body isnt able to handle the power without a new power to help control his eyes. Like I said once the Uchiha suffer they must keep suffering till they die, because their bodies cant handle the strain of their eyes.
Just as Madara and his brother suffered to gain their MS Madara tried to remedy his rebound with his brothers eyes. And finally Madara took hashis senju cells to yet again stabilize the power of his eyes, resulting in the acquisition of the rinnegan. Which is something that Itachi couldnt achieve one because the only living Uchiha were sasuke and tobi, and Itachi wouldnt take sasukes eyes.
Essentially Itachis illness was a rebound of his vast uncontrollable MS powers.
The most visible symptom of Itachi's illness is hemoptysis.*
The hemoptysis is, more likely than not, a result of diffuse alveolar hemorrhage. This is a classic symptom of MPA when it presents with pulmonary manifestations. There is also shortness of breath, and coughing.
Unlike many other forms of vasculitis, such as wegener granulomatosis for example, the upper respiratory tract is usually spared. All the damage is deeper in the lungs. Itachi's case is consistent with this.
You must be registered for see images
Other symptoms along the same vein can be seen during his final battle with Sasuke when Itachi grabs his shirt, reacting to what appears to be a heart attack.
Chest pain, myocardial infarction and other signs of cardiac failure are not uncommon effects of this disease, especially considering how it presented.*
You must be registered for see images
It is also no secret that by the time of his death, Itachi was nearly blind. This, we know, to be a direct result of the mangyeko sharingan. When the mangyeko is used, it clearly puts a tremendous amount of strain on the eye, and the nerves and blood vessels that surround it. Needless to say, it's inflammatory in and of itself. But it is hasty to assume that Itachi's eye problems are caused by the mangyeko alone.*
Ocular involvement in MPA is uncommon, but can exist - usually in the form of retinal hemorrhage and scleritis. The bloodshot eyes Itachi sports in his final battle with Sasuke show these symptoms clearly.*
You must be registered for see images
His low stamina as reported by the databook suggest constitutional symptoms of malaise and fatigue. The peculiar way he rests one hand in his cloak could be an attempt to alleviate painful sensations attributed to peripheral nervous system involvement manifesting as mononeuritis multiplex or myalgia, or simply to support a weakened limb. One could probably even argue his thin stature is evidence of weight loss.
You must be registered for see images
Lastly, we consider the prognosis.*
The average age of onset is usually in the fifth decade of life, but cases around Itachi's age have been reported in medical literature.
The cause of the disease is currently unknown.
It is seen as an auto-immune disorder,
But because it doesn't have a tendency to run in families, it's not viewed as genetic. (Sasuke, after all, is still healthy.) However, it is theorized that there needs to be a trigger event, such as a disease or a major bout of inflammation that sets the production of antibodies into overdrive. This trigger could easily be the initial, or repeated, activation of the mangyeko sharingan, which as stated before, is clearly inflammatory in and of itself.
