Judging by
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in part 1, Orochimaru can control Manda if he's healthy and in full power. Even without Manda, Oro has access to other boss snakes [
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]-[
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] that can still prove to be effective in most situations, like in this match. Oro can exude poison from his body in his "true" form, and obviously all of his snake summons carry poison in their fangs.
Kusanagi blade was damaging Hiruzen's diamond hard Adamantine staff, and didn't receive any damage from grazing KN4's corrosive chakra cloak. By feats and even databook hype, Kusanagi should be able to pierce through Domu with no problem.