Minato beat a kamui-equipped Obito, in spite of the element of surprise and not knowing anything about his abilities at the start of battle, while Obito knew Minato well. Ay, claimed to be one of the fastest at the time, couldn't land a hit on Minato. The only time Minato has been shown to suffer damage was when he acted as a shield to protect Naruto from Kurama (Edo doesn't count -- it changes battle tactics such that evading isn't important).
So, tell me, how on earth will 2 slowpokes like Tsunade and Sakura beat them?
Ways Minato can beat them:
<> Cut off their heads.
<> Teleport them to...anywhere, really. The sky, the ocean, under a mountain -- the possibilities are endless.
<> Food Card Destroy them'
<> Cut them in quarters, and (you've guessed it) TELEPORT THEM poles apart.
<> More teleporting
<> All of the above, with slight variations based on environment, because unlike the other two, Minato is actually aware of it.
Ways Tsunade/Sakura can beat them, even combined, with the help of summons, etc.: