You're being myopic. Madara took his actions because he sought the power of the TB. Rin was kidnapped to place a TB in her. Itachi revolted and killed the clan because they were seeking power in the village. Obito wanted to collect the TB and become God and change the world. Same with Nagato.
Sasuke's looking past all of it and seeing the real problem in the NV, which he sees as the TB and the concept of chakra. His version of being Hokage is to destroy the village system Hashirama made. In other words, Sasuke never accepted what Hashirama told him. He just realized Hashirama's naivety had been inherited by his brother and Naruto.
And how would destroying the TB change anything, people who want power will simply find another way to do it.
People killed each other and waged war long before the tailed beasts exist.
Also those were a result of Madara's actions, (and before him BZ), they set that whole situation in motion.
And Itachi killed his clan because they were planning a coup as a result of scrutiny from the elders, that had nothing to do with the Tailed Beasts, that was their own decision.
Also you said in your OP that the Sage thinks Sasuke is right, except that the Sage clearly said otherwise and that he trusted Naruto to handle Sasuke.
He said Sasuke was "no good." That isn't approval.