If Tsunade comes in close for her usual punch, Chidori Nagashi paralyzes her and Sasuke chops her up with his Chidori Katana. His wing let him survive Deidara's C2 bomb with minimal damage to his actual body. Both wings let him take Tsunade's punches with little damage to his actual body, allowing him to counter with something like snakes to bind her and then Chidori Katana to cut her apart. He doesn't even need to blitz her.
Sasuke stomps Tsunade. I'd like to actually see a good argument for Tsunade, but I highly doubt that it'll happen.