I would be happy if Kaguya is TNJ'ed, and it is quite possible, considering that Naruto's TNJs are effective when there lies some link between Naruto and the opponent.
However, Kaguya will need to be weakened physically and/or mentally in order for the TnJ to be effective. The Zabuza/Gaara/Nagato/Obito situations fit this mold. This means that Naruto and Sasuke will have to work together and show off their new powers (possibly something new up their sleeves? This is likely the case). Kaguya might have flashbacks or mental struggles; we still need to know more about her backstory, and these episodes could be vital for the effectiveness of the TnJ.
I expect Kushina to be referenced in this fight. A mother like Kushina, who loved, died for, and trusted Naruto [as did Minato], seems to differ greatly from the power-hungry Kaguya. This might contribute to Naruto's peace-making ability.
Overall, can't wait for the fight.