I believe she was speaking generally as well as specifically. Generally in the sense that if Orochimaru-sama been more positive, he and Jiraiya-sama would have taken down the Akatski. I'm sure although she could've meant a more broader picture, you can't but help think that if Oro was a better person in the series he could've have helped Jiraiya defeat or at least escape Pein at that time...
Also, there's no telling how much intel Oro had on Pein, Nagato and Tobi...makes me wonder if he even suspected Obito, or at least had some hint that Tobi was not the real Uchiha Madara?!