Tobirama water styles are weak, he's just more versatile of creating a lot of water in thin air, something that even the mizuakges are noted for doing, thats all to it, what he should be concerning with his the massive acid slime that spreads over 2oometers and if powered up by Tsunade it triple times that.
so yes you have a point if you asphyxiate her she probably die thats if you have a tongue jutsu like orochimaru plus that wont work either she would eventually retaliate in the same manner like when she beat the crap out of him, PLUS YOUR FORGETTING THAT SHE HAD REACHED THE END OF HER ENHANCED STRENGTH, hence why orochimaru survive, his organs were badly damaged commented by kabuto after that fight, his face was torn to shreds, PLEASE, STOP THIS MADNESS,
With Hiruzen smoke, i laughed at this, haven't you heard of anaerobic respiration what can smoke do to Tsunade, furthermore whenever she fuses with her slug they can communicate telepathically, and she can pass on all her jutsus via the animal for efficient kills, scapel, nervous disorders, chackra poisons, please dude, Hiruzen cant beat Tsunade enough said stop being a fanboy.
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Tsunade destroyed madara several times? Please show me some scans of this, several scans since she destroyed him several times. I will not reply until i see the scans.