Mate, this is ANBU Itachi. He hasn't shown Amaterasu and Susanoo. His Tsukuyomi has the power of a 14 year old. Do you really think a 14 year old's genjutsu is going to cripple Tsunade, who is in the durability top and is the ONLY ONE that managed to heal somebody from Tsukuyomi?
Itachi already stated that on the day he got Tsukuyomi, he had Amaterasu and Susanoo as well.
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Thus Amaterasu KO's her. Tsunade healing someone from Tsukuyomi's effects doesn't mean that she can survive it, useless comparison and durability has NOTHING to do with mental damage.
Well, if we take Sasuke's experiences into account, one doesn't simply master MS techniques when they first acquire them. Two His stamina would not have been that high using MS techniques as he would have perfected them to the point of efficiency yet.
You could argue that Tsunade can't break Tsukuyomi, but that's not a claim you can necessarily defend well. Furthermore, nothing suggests Tsunade would look in his eyes. And given how neither Tobirama or Hashirama seem to care to much about looking Sasuke in the eye, one could in fact argue that Senju may have a reason for being so unconcerned. She can't get through his Susanoo? Please tell me what level susanoo he had acquired at that time period. The only real threat possessed by Itachi at that time is Amaterasu.
It really doesn't matter what level of Susanoo he had because she isn't getting past a V1 Susanoo before she gets killed by Amaterasu or a Susanoo hand smashing her like it did Danzo. Also I cant argue her not being able to break Tsukuyomi? Yeah right. Manga has already stated that only an Uchiha who shares the same blood as Itachi can break it. Anyone who disagrees is simply going against the manga and their claims of her being able to break it are disregarded. Why would they care about looking Sasuke in the eye? They are under Oro's Edo Tensei first of all and Hashirama wants to talk to Sasuke so Sasuke wouldn't Genjutsu them because the rest of them can be made Oro's pawns and if he Genjutsus Hashirama he can't talk so that Senju may have a reason for being unconcerned argument holds no merit. Itachi showed no strain at all after using Tsukuyomi on Sasuke, using 1 Amaterasu and a V1 Susanoo isn't going to affect bad enough for him to lose this fight. She can't break Tsukuyomi and she can't dodge or heal Amaterasu so she loses.
Definitely an underestimation going on. 1. Susanoo is weak to acid. 2. Katsuyu has a stronger acid than Mei. 3. Tsunade would break through a weakened V2 Susanoo. 4. If a single punch is enough to crack Madara's V1, (which by the way stood up to the 4th Raikage's horizontal chop, when Sasuke's V1 was cracked by the same chop, which therefore would mean that not all Susanoo's have the same breaking point and I doubt you would be bold enough to say that Itachi's Susanoo was of the same strength as Madara), then sure repeated punches in the same spot would do the same able to accomplish the job.
Tsunade would not break through a V2 Susanoo, not when she didn't even get past a V1 of Madara's. Madara's may be stronger but Itachi's V2 Susanoo is obviously stronger than Madara's V1 Susanoo but that really doesn't matter in this thread so I'll leave it be. Katsuyu can be roasted with Amaterasu so her acid isn't a problem not like I was referring to her acid when I said she can't break through V2 with her fists.