Abilities
As Tsunade's first apprentice, Shizune is a very capable kunoichi and a highly talented medical-nin. Her abilities were acknowledged by the Sannin Jiraiya, who first went to her to counteract the drug that Tsunade had dosed him with, and later left Kabuto Yakushi up to her.[5] A further testament to her prowess was her being put in charge of the Logistical Support and Medical Division of the Allied Shinobi Forces during the Fourth Shinobi World War.[6]
Ninjutsu
Medical Ninjutsu
Shizune is noted to be a very talented medical ninja, surpassed only by Tsunade herself. Her prowess set a high standard for Tsunade's other disciples, as the Sannin noted that she had not seen someone with so much skill since Shizune while training Sakura Haruno.[7] Shizune's chakra control is great enough to perform even the most complex medical ninjutsu, leading Tsunade to have the utmost confidence in her. It was due to her control that she was assigned to lead the sealing of the Three-Tails.
Shizune demonstrated her great medical knowledge when she lead a group of medical ninja in a complicated procedure that took over three hours while the slightest mistake could be fatal.[8]
Poison Techniques and Weaponry
Poison Mist
Shizune has rarely been seen in battle, but from what has been seen of her skills so far is that she incorporates the use of poison-related techniques during combat. During her battle with Kabuto, Shizune showed the ability to use the Poison Mist technique, creating a thick cloud of toxic gas, capable of being fatal even if only a mere whiff is breathed in, as noted by Kabuto in the anime.[9]
Shizune is also skilled to use her poison in conjunction with her weaponry. She uses poisoned senbon in a variety of ways, like firing them from a concealed wrist-mounted device or spitting them out of her mouth in quick succession.[10][11] Kakashi Hatake mentioned that Shizune is also able to imbue a kunai with poison.[12]
Intelligence
Shizune is quite observant and has a keen intellect. This was seen when she was put in charge of the autopsy Konoha performed on the first Animal Path that Jiraiya had captured, where she and her team were able to find out the secret behind the chakra receivers embedded in the corpse after just a short amount of time.[13] Likewise, during the Fourth Shinobi World War, she could find out the DNA-similarities between the White Zetsu Army and the first Hokage Hashirama Senju, something that she already presumed before.[14]
Other Skills
In battle, Shizune is quite fast, and equally fierce and precise in her attacks.[15] She is also very adaptable to the situation and is able to perform immediate counters that are too fast for her opponents to react properly.[16] Shizune is also a gifted teacher as she could instruct Sakura on how to imbue her weapons with poison.[12]
In the anime, she has made use of the Shadow Clone Technique,[17] and has been shown to be able to create at least 36 clones at once. She also demonstrated capable skills in fūinjutsu, able to lead her team in the process of sealing a tailed beast. It was also shown that she was adept at using taijutsu, able to fight and defeat many of Naruto's shadow clones.[17]
