As Subject says... I honestly think her bish ass would .. even though Sasuke tried to kill her when she was fodder....
Naruto killing Sasuke doesn't even exist.
If Naruto does kill sasuke, then that make Naruto not becoming hokage more useless than ever.
If he had to chose weather he'd kill sasuke or become hokage he would probably chose to die or neither.
No, she wouldn't be mad at all. Naruto would only kill Sasuke if no other alternatives were left during their fight. She'd understand that Naruto tried his best. However, of course she would be sad for a while, just as Naruto himself would be as well as Kakashi.