No, she was the one trying to kill him a while back. She even said she will leave it to Sasuke and a Naruto last time they all met. She knows Naruto's resolve for saving Sasuke is strong and if Naruto felt like he had to kill Sasuke then there was no hope for him. Sasuke is currently threatening get teacher Tsunade life as well. Naruto already said he will save the Bijuus no matter what so he will save his current comrades even if he have to kill his ex comrade and now enemy of the 5 nations.As Subject says... I honestly think her bish ass would .. even though Sasuke tried to kill her when she was fodder....
He would be killing Sasuke to save his friends, the Bijuus, which he stated he will save no matter what he has to do. He is also fighting to save the 5 Kages who all voiced wanting to change the system for a more peaceful oneNaruto killing Sasuke doesn't even exist.
If Naruto does kill sasuke, then that make Naruto not becoming hokage more useless than ever.
If he had to chose weather he'd kill sasuke or become hokage he would probably chose to die or neither.
This^^^No, she wouldn't be mad at all. Naruto would only kill Sasuke if no other alternatives were left during their fight. She'd understand that Naruto tried his best. However, of course she would be sad for a while, just as Naruto himself would be as well as Kakashi.