why hashirama only..?

Behemoth55

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I mean to ask that why people use hashirama cells for activation of Rinnegan why not tobirama or tsunade they are also senju

Because only Hashiramas cells could enhance the physical energy so much.
 

Six Paths

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Because he was the strongest Senju to ever exist. His DNA gives the person very high chakra pools and even regenerative abilities that are more advanced than any other. Hashirama is a rare Gem among the Senju.
 

Joon

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Hashirama cells is a catalyst which can be exploited for new abilities.
 
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