Who can permanetly kill Orochimaru in one shot?

KGB Kakuzu

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Madara, Oonoiki, Muu, Itachi, Obito, Shinju, Hagoromo

Assuming no other curse seals exist to bring him back.



Basically anyone on possession of a one shot massive collateral damage technique: which virtually erases the existence of things. Itachi only for the Totsuka.




The only other theoretical is Shisui with a KA order to commit suicide: Lelouch vi Brittainia style.
 

Joker

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Madara, Oonoiki, Muu, Itachi, Obito, Shinju, Hagoromo

Assuming no other curse seals exist to bring him back.



Basically anyone on possession of a one shot massive collateral damage technique: which virtually erases the existence of things. Itachi only for the Totsuka.




The only other theoretical is Shisui with a KA order to commit suicide: Lelouch vi Brittainia style.
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It was a trick question, he lives within thousands.
 
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ANiMUS

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Only Kabuto and Sasuke know all of Orochimaru's methods & techs. so they are probably the only one who can defeat him, but one-shot and permanent is impossible because Orochi can be resurrected via curse seal.
 
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The Necromancer

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Killing him is killing him. When he's dead he needs support from an ally which means it's 2 on 1. If that's what you want then you need to specify.

Going by your logic, no one can be defeated in this manga because they can all be resurrected via edo tensei.
 
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