Without him using sage mode. Who can defeat hashirama.
Restrictions: Edo tensei
Don't count jubi jins. The sages family. Or anyone with the sages power
I will use no plot restriction, unlike Kishi manga.
The winner is:-
MS Obito - Kamui snipe.
DSM Kabuto - Tactic, strategies, weakness weapon
Minato Namikaze - FTG, strategies.
MS Itachi - If weapon of hype sustain it hype.
Danzo - Izanagi trick
Nagato - Rinnegan jutsu
Rinnegan Madara - name tell itself.
Actually to win on Hahirama, any Shinobi must be good at strategist, trick, speed and tactic for them to counter Hashi massive jutsu and wood clone faint.
Having a HAX is a plus for any shinobi that up against Hashi.
Thanks.